The Inner Membrane Protein HrcV from Xanthomonas spp. Is Involved in Substrate Docking During Type III Secretion
نویسندگان
چکیده
منابع مشابه
HrcQ Provides a Docking Site for Early and Late Type III Secretion Substrates from Xanthomonas
Pathogenicity of many Gram-negative bacteria depends on a type III secretion (T3S) system which translocates bacterial effector proteins into eukaryotic cells. The membrane-spanning secretion apparatus is associated with a cytoplasmic ATPase complex and a predicted cytoplasmic (C) ring structure which is proposed to provide a substrate docking platform for secreted proteins. In this study, we s...
متن کاملHpaC Controls Substrate Specificity of the Xanthomonas Type III Secretion System
The Gram-negative bacterial plant pathogen Xanthomonas campestris pv. vesicatoria employs a type III secretion (T3S) system to inject bacterial effector proteins into the host cell cytoplasm. One essential pathogenicity factor is HrpB2, which is secreted by the T3S system. We show that secretion of HrpB2 is suppressed by HpaC, which was previously identified as a T3S control protein. Since HpaC...
متن کاملIdentification of a novel type III secretion-associated outer membrane-bound protein from Xanthomonas campestris pv. campestris
Many bacterial pathogens employ the type III secretion system (T3SS) to translocate effector proteins into eukaryotic cells to overcome host defenses. To date, most of our knowledge about the T3SS molecular architecture comes from the studies on animal pathogens. In plant pathogens, nine Hrc proteins are believed to be structural components of the T3SS, of which HrcC and HrcJ form the outer and...
متن کاملA Substrate-Fusion Protein Is Trapped inside the Type III Secretion System Channel in Shigella flexneri
The Type III Secretion System (T3SS) is a macromolecular complex used by Gram-negative bacteria to secrete effector proteins from the cytoplasm across the bacterial envelope in a single step. For many pathogens, the T3SS is an essential virulence factor that enables the bacteria to interact with and manipulate their respective host. A characteristic structural feature of the T3SS is the needle ...
متن کاملThe inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system.
Type III secretion machines are essential for the biology of many bacteria that are pathogenic or symbiotic for animals, plants, or insects. They exert their function by delivering bacterial effector proteins into target eukaryotic cells. The core component of these machines is the needle complex, a multiprotein structure that spans the bacterial envelope and serves as a conduit for proteins th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Plant-Microbe Interactions®
سال: 2013
ISSN: 0894-0282,1943-7706
DOI: 10.1094/mpmi-01-13-0019-r